Modern scientific research has mostly focused on intravenously injected DMT. Its consumption has most traditionally occurred via drinking ‘Ayahuasca’, a brew composed of plant-based DMT and β –carbolines (monoamine oxidize inhibitors), which inhibit the GI breakdown of the DMT ( Buckholtz and Boggan, 1977). When ingested orally, DMT is metabolized in the gastrointestinal (GI) system before reaching the brain. For example, synthesized compound is smoked or injected but it has also been used more traditionally in ceremonial contexts (e.g. DMT, which is a classic psychedelic drug, is also taken exogenously by humans to alter the quality of their consciousness. N,N, Dimethyltryptamine (DMT) is a mixed serotonin receptor agonist that occurs endogenously in several organisms ( Christian et al., 1977 Nichols, 2016) including humans ( Smythies et al., 1979), albeit in trace concentrations. The robust hypothesis-confirming nature of these findings imply the discovery of an important mechanistic principle underpinning psychedelic-induced altered states. These results support a recent model proposing that psychedelics reduce the ‘precision-weighting of priors’, thus altering the balance of top-down versus bottom-up information passing. Moreover, the typical top-down alpha-band rhythms of closed-eyes rest were significantly decreased, while the bottom-up forward wave was significantly increased. travelling waves) similar to that elicited by visual stimulation. Consistent with our hypotheses, results revealed a spatio-temporal pattern of cortical activation (i.e. Here, we investigated the electrophysiological correlates of the DMT-induced altered state from a pool of participants receiving DMT and (separately) placebo (saline) while instructed to keep their eyes closed. N,N, Dimethyltryptamine (DMT) can rapidly induce an extremely immersive state of consciousness characterized by vivid and elaborate visual imagery. Psychedelic drugs are potent modulators of conscious states and therefore powerful tools for investigating their neurobiology.
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